Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met

ATP + L-Met + H2O → AdoMet + Pi + PPi

Reactome: R-HSA-5603114
Compartment: cytosol
Rhea: RHEA:21081

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
L-MetCHEBI:57844, C5H11NO2S, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

AdoMetCHEBI:59789, C15H23N6O5S, cytosol
PiCHEBI:43474, HO4P, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

methionine adenosyltransferase activity of MAT2B:MAT2A:K+:2Mg2+ [cytosol]EC 2.5.1.6

MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met

Inputs

Outputs

Catalysed by

Literature