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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP2R1 25-hydroxylates VD3 to 25(OH)D

VD3 + O2 + H+ + NADPH → 25(OH)D + H2O + NADP+

Reactome: R-HSA-209845
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

VD3CHEBI:28940, C27H44O, endoplasmic reticulum membrane
O2CHEBI:15379, O2, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Outputs

25(OH)DCHEBI:17933, C27H44O2, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

vitamin D3 25-hydroxylase activity of CYP2R1 [endoplasmic reticulum membrane]UniProt Q6VVX0

Literature

Metabolism of vitamin D by human microsomal CYP2R1 Biochem Biophys Res Commun, 2004
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase J. Biol. Chem., 2003