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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Arrows follow Reactome's curated reaction direction.

CYP2A13 oxidises AFM1 to AFM1E

AFM1 + H+ + NADPH + O2 → AFM1E + H2O + NADP+

Reactome: R-HSA-5423647
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

AFM1CHEBI:78576, C17H12O7, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

AFM1ECHEBI:78577, C17H12O8, cytosol
H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

monooxygenase activity of CYP2A13 [endoplasmic reticulum membrane]UniProt Q16696

Literature

Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract Int. J. Cancer, 2006