Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide
HALO + NADPH + H+ + O2 → TFAC + HBr + NADP+ + H2O
- Reactome
- R-HSA-76475
- Compartment
- smooth endoplasmic reticulum
- Rhea
- None recorded
Inputs
- HALOCHEBI:5615, C2HBrClF3, endoplasmic reticulum lumen
- NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
Outputs
- TFACCHEBI:29138, C2ClF3O, endoplasmic reticulum lumen
- HBrCHEBI:47266, HBr, endoplasmic reticulum lumen
- NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
Catalysed by
- monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]