Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP7A1 7-hydroxylates CHOL

CHOL + NADPH + H+ + O2 → H2O + NADP+ + 7 alpha-hydroxycholesterol

Reactome: R-HSA-192051
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:21813

Inputs

CHOLCHEBI:16113, C27H46O, endoplasmic reticulum membrane
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
7 alpha-hydroxycholesterolCHEBI:17500, C27H46O2, endoplasmic reticulum membrane

Catalysed by

cholesterol 7-alpha-monooxygenase activity of CYP7A1 [endoplasmic reticulum membrane]EC 1.14.14.23; UniProt P22680

Literature

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase FEBS Lett, 1990