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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SULT1A3,4 dimers sulfate DA to DAOS

DA + PAPS → DAOS + PAP

Reactome: R-HSA-159358
Compartment: cytosol
Rhea: RHEA:67881

Inputs

DACHEBI:59905, C8H12NO2, cytosol
PAPSCHEBI:58339, C10H11N5O13P2S, cytosol

Outputs

DAOSCHEBI:37946, C8H11NO5S, cytosol
PAPCHEBI:58343, C10H11N5O10P2, cytosol

Catalysed by

aryl sulfotransferase activity of SULT1A3,4 dimers [cytosol]EC 2.8.2.1

Literature

Thermolabile and thermostable human platelet phenol sulfotransferase. Substrate specificity and physical separation. Naunyn Schmiedebergs Arch Pharmacol, 1983
Radioenzymatic assay of sulfate conjugates of catecholamines and DOPA in plasma Life Sci, 1980
Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism J. Neurochem., 2003
Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies Biochem. Biophys. Res. Commun., 2004