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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP7B1 7-hydroxylates 25OH-CHOL

25OH-CHOL + NADPH + H+ + O2 → CHOL3b,7a,25TRIOL + H2O + NADP+

Reactome: R-HSA-192065
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:24309

Inputs

25OH-CHOLCHEBI:42977, C27H46O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

CHOL3b,7a,25TRIOLCHEBI:37623, C27H46O3, cytosol
H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]

Literature

Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1 J Lipid Res, 1999