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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NQO2:FAD dimer reduces quinones to hydroquinones

quinone + RFDHN → hydroquinone + RFNA

Reactome: R-HSA-8936519
Compartment: cytosol
Rhea: None recorded

Inputs

quinoneCHEBI:36141, cytosol
RFDHNCHEBI:55458, C11H16N2O5, cytosol

Outputs

hydroquinoneCHEBI:17594, C6H6O2, cytosol
RFNACHEBI:15927, C11H15N2O5, cytosol

Catalysed by

dihydronicotinamide riboside quinone reductase activity of NQO2:FAD dimer [cytosol]EC 1.10.5.1

Literature

Crystal structure of quinone reductase 2 in complex with resveratrol Biochemistry, 2004
Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2 Biochem. J., 2008
Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase Arch. Biochem. Biophys., 1997
NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs Biochem. Pharmacol., 2006
Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy Cancer Res., 2000
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science, 1997