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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP46A1 24-hydroxylates CHOL

CHOL + NADPH + H+ + O2 → 24OH-CHOL + NADP+ + H2O

Reactome: R-HSA-192061
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:22717

Inputs

CHOLCHEBI:16113, C27H46O, endoplasmic reticulum membrane
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

24OH-CHOLCHEBI:34310, C27H46O2, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

cholesterol 24-hydroxylase activity of CYP46A1 [endoplasmic reticulum membrane]EC 1.14.14.25; UniProt Q9Y6A2

Literature

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain Biochemistry, 2003
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain Proc Natl Acad Sci U S A, 1999