CES1 trimer.CES2 hydrolyse COCN to BEG
H2O + COCN → BEG + MeOH + H+
- Reactome
- R-HSA-5693691
- Compartment
- endoplasmic reticulum lumen
- Rhea
- None recorded
Inputs
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
- COCNCHEBI:27958, C17H21NO4, endoplasmic reticulum lumen
Outputs
- BEGCHEBI:41001, C16H19NO4, endoplasmic reticulum lumen
- MeOHCHEBI:17790, CH4O, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
Catalysed by
- carboxylic ester hydrolase activity of CES1 trimer, CES2 [endoplasmic reticulum lumen]EC 3.1.1.1
Literature
- Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine Biochem. Pharmacol., 1994
- Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin J. Biol. Chem., 1997
- Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition Chem. Biol., 2003