CYP3A4 can N-demethylate loperamide
LPAM + H+ + NADPH + O2 → N-demethylated loperamide + H2O + NADP+
- Reactome
- R-HSA-211948
- Compartment
- endoplasmic reticulum membrane · endoplasmic reticulum lumen
- Rhea
- None recorded
Inputs
- LPAMCHEBI:6532, C29H33ClN2O2, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
- NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
Outputs
- N-demethylated loperamideCHEBI:64043, C28H31ClN2O2, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
- NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
Catalysed by
- monooxygenase activity of Cytochrome P450 (CYPIIIA4 based) [endoplasmic reticulum membrane]