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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP

PAPS + PNP → PAP + p-nitrophenol sulfate

Reactome: R-HSA-176646
Compartment: cytosol
Rhea: RHEA:66549

Inputs

PAPSCHEBI:58339, C10H11N5O13P2S, cytosol
PNPCHEBI:16836, C6H5NO3, cytosol

Outputs

PAPCHEBI:58343, C10H11N5O10P2, cytosol
p-nitrophenol sulfateCHEBI:35422, C6H5NO6S, cytosol

Catalysed by

aryl sulfotransferase activity of SULT1A1,A2,C2,4A1 [cytosol]EC 2.8.2.1

Literature

Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization Gene, 2002
Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene J Biol Chem, 1998
Structural and functional characterisation of human sulfotransferases Chem Biol Interact, 1998
cDNA cloning and expression of a new form of human aryl sulfotransferase Int J Biochem Cell Biol, 1996