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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AHR:TCDD binds ARNT

AHR:TCDD + ARNT, ARNT2 → AHR:TCDD:ARNT

Reactome: R-HSA-8937177
Compartment: nucleoplasm
Rhea: None recorded

Inputs

AHR:TCDDR-HSA-8937150, nucleoplasm
ARNT, ARNT2R-HSA-8936837, nucleoplasm

Outputs

AHR:TCDD:ARNTR-HSA-8937203, nucleoplasm

Catalysed by

DNA-binding transcription activator activity, RNA polymerase II-specific of ARNT, ARNT2 [nucleoplasm]

Literature

Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt Mol. Cell. Biol., 1999