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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GSH translocates from cytosol to extracellular region

GSH → GSH

Reactome: R-HSA-1247915
Compartment: plasma membrane
Rhea: RHEA:74819

Inputs

GSHCHEBI:57925, C10H16N3O6S, cytosol

Outputs

GSHCHEBI:16856, C10H17N3O6S, extracellular region

Literature

Translocation of intracellular glutathione to membrane-bound gamma-glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle: glutathionuria after inhibition of transpeptidase Proc Natl Acad Sci U S A, 1979
Transport of gamma-glutamyl amino acids: role of glutathione and gamma-glutamyl transpeptidase Proc Natl Acad Sci U S A, 1979