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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP19A1 hydroxylates ANDST to E1

ANDST + 3 NADPH + 3 H+ + 3 O2 → 4 H+ + E1 + 3 NADP+ + 4 H2O + HCOOH

Reactome: R-HSA-193060
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:38196

Inputs

ANDSTCHEBI:16422, C19H26O2, cytosol
3 NADPHCHEBI:57783, C21H26N7O17P3, cytosol
3 H+CHEBI:15378, H, cytosol
3 O2CHEBI:15379, O2, cytosol

Outputs

4 H+CHEBI:15378, H, cytosol
E1CHEBI:17263, C18H22O2, cytosol
3 NADP+CHEBI:58349, C21H25N7O17P3, cytosol
4 H2OCHEBI:15377, H2O, cytosol
HCOOHCHEBI:15740, CHO2, cytosol

Catalysed by

steroid hydroxylase activity of CYP19A1 [endoplasmic reticulum membrane]UniProt P11511

Literature

Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis Endocr Rev, 1994
Structural and functional characterization of human aromatase P-450 gene Eur J Biochem, 1990