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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FMO1:FAD N-oxidises TAM

O2 + NADPH + H+ + TAM → TAMO + H2O + NADP+

Reactome: R-HSA-217255
Compartment: smooth endoplasmic reticulum
Rhea: None recorded

Inputs

O2CHEBI:15379, O2, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen
TAMR-ALL-9838650, endoplasmic reticulum lumen

Outputs

TAMOCHEBI:63825, C26H29NO2, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen

Catalysed by

N,N-dimethylaniline monooxygenase activity of FMO1:FAD [endoplasmic reticulum membrane]EC 1.14.13.8

Literature

Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin Drug Metab Dispos, 2005