CYP51A1 demethylates LAN

LAN + 3 H+ + 3 NADPH + 3 O2 → 4,4DMCHtOL + HCOOH + 4 H2O + 3 NADP+

Reactome

R-HSA-194678

Compartment

cytosol · endoplasmic reticulum membrane

Rhea

RHEA:25287

Catalysed by

• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom…EC 1.14.14.1; UniProt Q16850

Literature

1. The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols Arch Biochem Biophys, 1996
2. Structural basis of human CYP51 inhibition by antifungal azoles J. Mol. Biol., 2010