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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

estrone + PAPS => estrone 3-sulfate + PAP

PAPS + E1 → PAP + E1S

Reactome: R-HSA-176664
Compartment: cytosol
Rhea: RHEA:15974

Inputs

PAPSCHEBI:58339, C10H11N5O13P2S, cytosol
E1CHEBI:17263, C18H22O2, cytosol

Outputs

PAPCHEBI:58343, C10H11N5O10P2, cytosol
E1SCHEBI:60050, C18H21O5S, cytosol

Catalysed by

estrone sulfotransferase activity of SULT1E1,2A1 [cytosol]EC 2.8.2.4

Literature

Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase J Steroid Biochem Mol Biol, 1995
Cloning and expression of human liver dehydroepiandrosterone sulphotransferase Biochem J, 1993
Human liver estrogen sulfotransferase: identification by cDNA cloning and expression Biochem Biophys Res Commun, 1994