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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GLYAT-like proteins transfer glycine to aminobenzoyl-CoA

Gly + PABA-CoA → CoA-SH + PAH + H+

Reactome: R-HSA-9972916
Compartment: mitochondrial matrix
Rhea: RHEA:19870

Inputs

GlyCHEBI:57305, C2H5NO2, mitochondrial matrix
PABA-CoACHEBI:188497, C28H37N8O17P3S, cytosol

Outputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
PAHCHEBI:64703, C9H9N2O3, cytosol
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

glycine N-benzoyltransferase activity of GLYAT-like proteins [mitochondrial matrix]EC 2.3.1.71

Literature

Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver Biochem Biophys Res Commun, 1994
Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function Clin Biochem, 1995