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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP3A43 6b-hydroxylates TEST

TES + NADPH + H+ + O2 → H2O + NADP+ + 6BHT

Reactome: R-HSA-211959
Compartment: smooth endoplasmic reticulum
Rhea: None recorded

Inputs

TESCHEBI:17347, C19H28O2, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen

Outputs

H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
6BHTCHEBI:34477, C19H28O3, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of CYP3A43 [endoplasmic reticulum membrane]UniProt Q9HB55

Literature

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450 Mol Pharmacol, 2001
CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer Cancer Res, 2004