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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MAOA inhibitors bind MAOA:FAD

MAOA:FAD + MAOA Inhibitors → MAOA:FAD:MAOA Inhibitors

Reactome: R-HSA-9677917
Compartment: cytosol · mitochondrial outer membrane
Rhea: None recorded

Inputs

MAOA:FADR-HSA-141332, mitochondrial outer membrane
MAOA InhibitorsR-ALL-9677898, cytosol

Outputs

MAOA:FAD:MAOA InhibitorsR-HSA-9677899, mitochondrial outer membrane

Literature

Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers Neuro Endocrinol Lett, 2010
Structural and mechanistic studies of arylalkylhydrazine inhibition of human monoamine oxidases A and B Biochemistry, 2008
Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies Bioorg. Med. Chem. Lett., 2011
Fluorinated phenylcyclopropylamines. Part 3: Inhibition of monoamine oxidase A and B Bioorg. Med. Chem., 2004
Moclobemide. An update of its pharmacological properties and therapeutic use Drugs, 1996
Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors Int J Neuropsychopharmacol, 2015