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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AKR dimers reduce AFBDHO to AFBDOH

NADPH + H+ + AFBDHO → NADP+ + AFBDOH

Reactome: R-HSA-5423637
Compartment: cytosol
Rhea: None recorded

Inputs

NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
AFBDHOCHEBI:53107, C17H14O8, cytosol

Outputs

NADP+CHEBI:58349, C21H25N7O17P3, cytosol
AFBDOHCHEBI:53108, C17H18O8, cytosol

Catalysed by

alcohol dehydrogenase (NADP+) activity of AKR dimers [cytosol]EC 1.1.1.2

Literature

Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase Biochem. J., 1998
Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3 Chem. Res. Toxicol., 2008
Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter Carcinogenesis, 2003
Aldo-keto reductases and bioactivation/detoxication Annu. Rev. Pharmacol. Toxicol., 2007
Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases Chem. Res. Toxicol., 2001