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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AOC1 deaminates Hist

Hist + H2O + O2 → I4AH + NH3 + H2O2 + H+

Reactome: R-HSA-5696131
Compartment: extracellular region · plasma membrane
Rhea: RHEA:25626

Inputs

HistCHEBI:58432, C5H10N3, extracellular region
H2OCHEBI:15377, H2O, extracellular region
O2CHEBI:15379, O2, extracellular region

Outputs

I4AHCHEBI:27398, C5H6N2O, extracellular region
NH3CHEBI:16134, H3N, extracellular region
H2O2CHEBI:16240, H2O2, extracellular region
H+CHEBI:15378, H, extracellular region

Catalysed by

histamine oxidase activity of AOC1 dimer:2xCu2+:4xCa2+ [plasma membrane]EC 1.4.3.22

Literature

Structure and inhibition of human diamine oxidase Biochemistry, 2009