ALD3A1 oxidises 4HPCP to CXPA
4HPCP + H2O + NADP+ → CXPA + H+ + NADPH
- Reactome
- R-HSA-5692283
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- 4HPCPCHEBI:196991, C7H15Cl2N2O4P, cytosol
- H2OCHEBI:15377, H2O, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Outputs
- CXPACHEBI:3410, C7H15Cl2N2O4P, cytosol
- H+CHEBI:15378, H, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
Catalysed by
- aldehyde dehydrogenase [NAD(P)+] activity of ALDH3A1 [cytosol]EC 1.2.1.5; UniProt P30838
Literature
- RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide Cancer Chemother. Pharmacol., 2007
- Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity Chembiochem, 2014