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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MAOA:FAD oxidatively deaminates of 5HT

O2 + H2O + 5HT → 5HIALD + H2O2 + NH4+

Reactome: R-HSA-141186
Compartment: cytosol · mitochondrial outer membrane
Rhea: RHEA:69073

Inputs

O2CHEBI:15379, O2, cytosol
H2OCHEBI:15377, H2O, cytosol
5HTCHEBI:350546, C10H13N2O, cytosol

Outputs

5HIALDCHEBI:50157, C10H9NO2, cytosol
H2O2CHEBI:16240, H2O2, cytosol
NH4+CHEBI:28938, H4N, cytosol

Catalysed by

primary methylamine oxidase activity of MAOA:FAD [mitochondrial outer membrane]EC 1.4.3.21

Literature

The deamination of dopamine by human brain monoamine oxidase. Specificity for the two enzyme forms in seven brain regions Naunyn Schmiedebergs Arch Pharmacol, 1983
Monoamine oxidase A from human placenta and monoamine oxidase B from bovine liver both have one FAD per subunit Biochem. J., 1989