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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG

BMG + UDP-GlcA → BDG + UDP

Reactome: R-HSA-9632038
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

BMGCHEBI:16427, C39H44N4O12, endoplasmic reticulum lumen
UDP-GlcACHEBI:58052, C15H19N2O18P2, endoplasmic reticulum lumen

Outputs

BDGCHEBI:58471, C45H50N4O18, endoplasmic reticulum lumen
UDPCHEBI:58223, C9H11N2O12P2, endoplasmic reticulum lumen

Catalysed by

glucuronosyltransferase activity of UGT1A1 tetramer [endoplasmic reticulum membrane]EC 2.4.1.17

Literature

The hepatic microsomal formation of bilirubin diglucuronide J Biol Chem, 1983
Bilirubin mono- and diglucuronide formation by human liver in vitro: assay by high-pressure liquid chromatography Hepatology, 1981
Microsomal UDP-glucuronyltransferase-catalyzed bilirubin diglucuronide formation in human liver J Hepatol, 1986
Bilirubin conjugates in bile of man and rat in the normal state and in liver disease J Clin Invest, 1972