CYP4F8 19-hydroxylates PGH2
PGH2 + NADPH + H+ + O2 → NADP+ + H2O + 19OH-PGH2
- Reactome
- R-HSA-211919
- Compartment
- smooth endoplasmic reticulum
- Rhea
- None recorded
Inputs
- PGH2CHEBI:57405, C20H31O5, endoplasmic reticulum lumen
- NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
- O2CHEBI:15379, O2, endoplasmic reticulum lumen
Outputs
- NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
- 19OH-PGH2CHEBI:63912, C20H32O6, endoplasmic reticulum lumen
Catalysed by
- monooxygenase activity of Cytochrome P450 (CYP4F8 based) [endoplasmic reticulum membrane]
Literature
- Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides J Biol Chem, 2000
- Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles Biochem Biophys Res Commun, 1999