Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FMO2:FAD:Mg2+ S-oxidises MTZ

MTZ + NADPH + H+ + O2 → MTZ-SOX + NADP+ + H2O

Reactome: R-HSA-217258
Compartment: smooth endoplasmic reticulum
Rhea: None recorded

Inputs

MTZCHEBI:50673, C4H6N2S, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen

Outputs

MTZ-SOXCHEBI:63828, C4H6N2OS, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of FMO2:FAD:Mg2+ [endoplasmic reticulum membrane]

Literature

Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein Drug Metab Dispos, 2002