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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MEOS oxidizes ethanol to acetaldehyde

EtOH + NADPH + H+ + O2 → CH3CHO + 2 H2O + NADP+

Reactome: R-HSA-143468
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

EtOHCHEBI:16236, C2H6O, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen

Outputs

CH3CHOCHEBI:15343, C2H4O, endoplasmic reticulum lumen
2 H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]

Literature

Ethanol metabolism, cirrhosis and alcoholism Clin Chim Acta, 1997
Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system Alcohol Clin Exp Res, 1998
Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s J Pharmacol Exp Ther, 1996