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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

EPHX1 hydrates BaP4,5O to BaP4,5-DHD

BaP4,5O + H2O → BaP4,5-DHD

Reactome: R-HSA-5694077
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

BaP4,5OCHEBI:34560, C20H12O, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

BaP4,5-DHDCHEBI:81621, C20H14O2, cytosol

Catalysed by

cis-stilbene-oxide hydrolase activity of EPHX1 [endoplasmic reticulum membrane]EC 3.3.2.9; UniProt P07099

Literature

Functional analysis of human microsomal epoxide hydrolase genetic variants Chem. Biol. Interact., 2004
Epoxide hydrolases: biochemistry and molecular biology Chem. Biol. Interact., 2000