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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 → AHR:TCDD:2xHSP90AB1:AIP:PTGES3

Reactome: R-HSA-8937169
Compartment: cytosol · nucleoplasm
Rhea: None recorded

Inputs

AHR:TCDD:2xHSP90AB1:AIP:PTGES3R-HSA-8936846, cytosol

Outputs

AHR:TCDD:2xHSP90AB1:AIP:PTGES3R-HSA-8937154, nucleoplasm

Catalysed by

nuclear receptor activity of AHR:TCDD:2xHSP90AB1:AIP:PTGES3 [cytosol]

Literature

The aryl hydrocarbon receptor complex and the control of gene expression Crit. Rev. Eukaryot. Gene Expr., 2008
The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor Mol. Cell. Biol., 2001