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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NAT2 acetylation

NAT2 substrate + AcC-NAT2 → NAT2 acetylated conjugate + NAT2

Reactome: R-HSA-174967
Compartment: cytosol
Rhea: None recorded

Inputs

NAT2 substrateR-ALL-174971, cytosol
AcC-NAT2R-HSA-158833, cytosol

Outputs

NAT2 acetylated conjugateR-ALL-174958, cytosol
NAT2R-HSA-158692, cytosol

Catalysed by

arylamine N-acetyltransferase activity of AcC-NAT2 [cytosol]EC 2.3.1.5; UniProt P11245

Literature

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases Carcinogenesis, 1993
N-acetyltransferases, O-acetyltransferases, and N,O-acetyltransferases: enzymology and bioactivation Adv. Pharmacol., 1994
Arylamine N-acetyltransferases: a structural perspective Br. J. Pharmacol., 2013