Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TPMT transfers CH3 from AdoMet to 6MP

6MP + AdoMet → 6MMP + AdoHcy + H+

Reactome: R-HSA-158609
Compartment: cytosol
Rhea: None recorded

Inputs

6MPCHEBI:2208, C5H4N4S, cytosol
AdoMetCHEBI:59789, C15H23N6O5S, cytosol

Outputs

6MMPCHEBI:28279, C6H6N4S, cytosol
AdoHcyCHEBI:57856, C14H20N6O5S, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

thiopurine S-methyltransferase activity of TPMT [cytosol]EC 2.1.1.67; UniProt P51580

Literature

Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues. J Biol Chem, 1963
Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase Annu Rev Pharmacol Toxicol, 1999
The thiopurines: an update Invest New Drugs, 2005
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations Dig Liver Dis, 2005
Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia Iran J Ped Hematol Oncol, 2014