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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACSM2B-like proteins transform ST to ST-CoA

ST + ATP + CoA-SH → ST-CoA + AMP + PPi

Reactome: R-HSA-159567
Compartment: mitochondrial matrix
Rhea: RHEA:61669

Inputs

STCHEBI:30762, C7H5O3, mitochondrial matrix
ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Outputs

ST-CoACHEBI:32587, C28H40N7O18P3S, mitochondrial matrix
AMPCHEBI:456215, C10H12N5O7P, mitochondrial matrix
PPiCHEBI:33019, HO7P2, mitochondrial matrix

Catalysed by

CoA-ligase activity of ACSM2B-like proteins [mitochondrial matrix]

Literature

Pharmacokinetics of salicylate elimination in man J Pharm Sci, 1965
Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria J Biochem Mol Toxicol, 2003