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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AHRR binds ARNT

AHRR + ARNT, ARNT2 → AHRR:ARNT

Reactome: R-HSA-8936851
Compartment: cytosol
Rhea: None recorded

Inputs

AHRRR-HSA-8936841, nucleoplasm
ARNT, ARNT2R-HSA-8936837, nucleoplasm

Outputs

AHRR:ARNTR-HSA-8936835, nucleoplasm

Catalysed by

DNA-binding transcription repressor activity, RNA polymerase II-specific of AHRR [nucleoplasm]UniProt A9YTQ3

Literature

Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor Biochem. Biophys. Res. Commun., 2007
Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor Biochem. Pharmacol., 2009
Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator Mol. Pharmacol., 2008