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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GSTO1 dimer reduces methylarsonate to methylarsonite

methylarsonate + 2 GSH → methylarsonite + GSSG + H2O

Reactome: R-HSA-5696230
Compartment: cytosol
Rhea: RHEA:15970

Inputs

methylarsonateCHEBI:33409, CH4AsO3, cytosol
2 GSHCHEBI:57925, C10H16N3O6S, cytosol

Outputs

methylarsoniteCHEBI:14597, CH3AsO2, cytosol
GSSGCHEBI:58297, C20H30N6O12S2, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

methylarsonate reductase activity of GSTO1 dimer [cytosol]EC 1.20.4.2

Literature

Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily Chem. Res. Toxicol., 2001