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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP4F22 20-hydroxylates TrXA3

H+ + NADPH + O2 + TrXA3 → H2O + NADP+ + 20OH-TrXA3

Reactome: R-HSA-5602295
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
O2CHEBI:15379, O2, cytosol
TrXA3CHEBI:57448, C20H33O5, cytosol

Outputs

H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
20OH-TrXA3CHEBI:83782, C20H34O6, cytosol

Catalysed by

monooxygenase activity of CYP4F22 [endoplasmic reticulum membrane]UniProt Q6NT55

Literature

Mutations in a new cytochrome P450 gene in lamellar ichthyosis type 3 Hum Mol Genet, 2006