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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

UGT1A10 transfers GlcA from UDP-GlcA to GCTN

GCTN + UDP-GlcA → GCTN4OG + UDP

Reactome: R-HSA-8941701
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: None recorded

Inputs

GCTNCHEBI:34778, C16H12O5, endoplasmic reticulum lumen
UDP-GlcACHEBI:58052, C15H19N2O18P2, endoplasmic reticulum lumen

Outputs

GCTN4OGCHEBI:747564, C22H19O11, endoplasmic reticulum lumen
UDPCHEBI:58223, C9H11N2O12P2, endoplasmic reticulum lumen

Catalysed by

glucuronosyltransferase activity of UGT1A10 [endoplasmic reticulum membrane]EC 2.4.1.17; UniProt Q9HAW8

Literature

Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones Mol. Pharm., 2009
Natural Polyphenols for Prevention and Treatment of Cancer Nutrients, 2016
Commentary: bioavailability of flavonoids and polyphenols: call to arms Mol. Pharm., 2007