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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Formation of N-glucuronides

UDP-GlcA + N-centre functional group substrate → UDP + N-glucuronide

Reactome: R-HSA-174916
Compartment: endoplasmic reticulum lumen · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

UDP-GlcACHEBI:58052, C15H19N2O18P2, endoplasmic reticulum lumen
N-centre functional group substrateR-ALL-174932, endoplasmic reticulum lumen

Outputs

UDPCHEBI:58223, C9H11N2O12P2, endoplasmic reticulum lumen
N-glucuronideR-ALL-174918, endoplasmic reticulum lumen

Catalysed by

glucuronosyltransferase activity of UGT1A3,A4,A9 [endoplasmic reticulum membrane]EC 2.4.1.17

Literature

Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes Drug Metab Dispos, 2002
N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases Drug Metab Dispos, 2003
Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4 Biochem Pharmacol, 2004