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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP11B1 oxidises 11DCORT

11DCORT + 2 NADPH + 2 H+ + O2 → CORT + 2 NADP+ + H2O

Reactome: R-HSA-193997
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: RHEA:46101

Inputs

11DCORTCHEBI:28324, C21H30O4, mitochondrial matrix
2 NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
2 H+CHEBI:15378, H, mitochondrial matrix
O2CHEBI:15379, O2, mitochondrial matrix

Outputs

CORTCHEBI:17650, C21H30O5, mitochondrial matrix
2 NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Catalysed by

steroid 11-beta-monooxygenase activity of Cytochrome P450 (CYP11B1 based) [mitochondrial inner membrane]EC 1.14.15.4

Literature

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta) J Biol Chem, 1989
Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans Proc Natl Acad Sci U S A, 1992
A critical review of the origin and control of adrenal androgens Baillieres Clin Obstet Gynaecol, 1997