Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AADAC deacetylates PHEN

PHEN + H2O → 4-ethoxyaniline + acetyl group

Reactome: R-HSA-5689000
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

PHENCHEBI:8050, C10H13NO2, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

4-ethoxyanilineCHEBI:85505, C8H11NO, cytosol
acetyl groupCHEBI:40574, C2H3O, cytosol

Catalysed by

deacetylase activity of AADAC [endoplasmic reticulum membrane]UniProt P22760

Literature

Arylacetamide deacetylase is a determinant enzyme for the difference in hydrolase activities of phenacetin and acetaminophen Drug Metab. Dispos., 2010
The emerging role of human esterases Drug Metab. Pharmacokinet., 2012