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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP26C1 4-hydroxylates 9cRA

9cRA + NADPH + H+ + O2 → 4OH-9cRA + NADP+ + H2O

Reactome: R-HSA-211923
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

9cRACHEBI:50648, C20H28O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

4OH-9cRACHEBI:63802, C20H28O3, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

retinoic acid 4-hydroxylase activity of CYP26C1 [endoplasmic reticulum membrane]UniProt Q6V0L0

Literature

A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid J Biol Chem, 2004