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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AHR:2xHSP90:AIP:PTGES3 binds TCDD

AHR:2xHSP90AB1:AIP:PTGES3 + TCDD → AHR:TCDD:2xHSP90AB1:AIP:PTGES3

Reactome: R-HSA-8936849
Compartment: cytosol
Rhea: None recorded

Inputs

AHR:2xHSP90AB1:AIP:PTGES3R-HSA-8936844, cytosol
TCDDCHEBI:28119, C12H4Cl4O2, cytosol

Outputs

AHR:TCDD:2xHSP90AB1:AIP:PTGES3R-HSA-8936846, cytosol

Catalysed by

nuclear receptor activity of AHR:2xHSP90AB1:AIP:PTGES3 [cytosol]

Literature

p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines Biochem. Pharmacol., 2012
Stable association of hsp90 and p23, but Not hsp70, with active human telomerase J Biol Chem, 2001
Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors J. Biol. Chem., 1994
Functional role of AhR in the expression of toxic effects by TCDD Biochim. Biophys. Acta, 2003
The aryl hydrocarbon receptor complex and the control of gene expression Crit. Rev. Eukaryot. Gene Expr., 2008
Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity Mol. Cell. Biol., 1998