Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

cholesterol + PAPS => cholesterol sulfate + PAP

PAPS + CHOL → PAP + cholesterol sulfate

Reactome: R-HSA-176609
Compartment: cytosol
Rhea: RHEA:52369

Inputs

PAPSCHEBI:58339, C10H11N5O13P2S, cytosol
CHOLCHEBI:16113, C27H46O, cytosol

Outputs

PAPCHEBI:58343, C10H11N5O10P2, cytosol
cholesterol sulfateCHEBI:136579, C27H45O4S, cytosol

Catalysed by

alcohol sulfotransferase activity of SULT2B1-1 dimer [cytosol]EC 2.8.2.2

cholesterol + PAPS => cholesterol sulfate + PAP

Inputs

Outputs

Catalysed by

Literature