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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PAO:FAD oxidises NASPM to PTCN

NASPM + H2O + O2 → PTCN + H2O2 + 3AAPNAL

Reactome: R-HSA-141348
Compartment: peroxisomal matrix
Rhea: RHEA:25813

Inputs

NASPMCHEBI:58324, C9H23N3O, peroxisomal matrix
H2OCHEBI:15377, H2O, peroxisomal matrix
O2CHEBI:15379, O2, peroxisomal matrix

Outputs

PTCNCHEBI:326268, C4H14N2, peroxisomal matrix
H2O2CHEBI:16240, H2O2, peroxisomal matrix
3AAPNALCHEBI:30322, C5H9NO2, peroxisomal matrix

Catalysed by

N(1)-acetylpolyamine oxidase activity of PAOX:FAD [peroxisomal matrix]EC 1.5.3.13

Literature

Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion Biochem J, 2003