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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP

PAPS + EST17b → PAP + E2-SO4

Reactome: R-HSA-176521
Compartment: cytosol
Rhea: RHEA:52373

Inputs

PAPSCHEBI:58339, C10H11N5O13P2S, cytosol
EST17bCHEBI:16469, C18H24O2, cytosol

Outputs

PAPCHEBI:58343, C10H11N5O10P2, cytosol
E2-SO4CHEBI:4866, C18H24O5S, cytosol

Catalysed by

steroid sulfotransferase activity of SULT1E1 dimer [cytosol]EC 2.8.2.15

Literature

Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase J Steroid Biochem Mol Biol, 1995