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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP24A1 24-hydroxylates CTL

CTL + NADPH + H+ + O2 → CTLA + NADP+ + H2O

Reactome: R-HSA-211950
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: None recorded

Inputs

CTLCHEBI:17823, C27H44O3, mitochondrial matrix
NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix
O2CHEBI:15379, O2, mitochondrial matrix

Outputs

CTLACHEBI:63911, C27H44O4, mitochondrial matrix
NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Catalysed by

1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity of CYP24A1 [mitochondrial inner membrane]UniProt Q07973

Literature

Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone Proc Natl Acad Sci U S A, 2007
Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme Biochemistry, 1996
Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24 Eur J Biochem, 2000