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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation

O2 + NADPH + H+ + TBM → HTOLB + H2O + NADP+

Reactome: R-HSA-211988
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: None recorded

Inputs

O2CHEBI:15379, O2, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen
TBMR-ALL-9838902, endoplasmic reticulum lumen

Outputs

HTOLBCHEBI:63799, C12H18N2O4S, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane]

Literature

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9 Biochem Biophys Res Commun, 1991