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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG

AFXBO-CG,AFNBO-CG → AFXBO-C,AFNBO-C + Gly

Reactome: R-HSA-5433067
Compartment: plasma membrane · extracellular region
Rhea: None recorded

Inputs

AFXBO-CG,AFNBO-CGR-ALL-5490235, extracellular region

Outputs

AFXBO-C,AFNBO-CR-ALL-5490250, extracellular region
GlyCHEBI:57305, C2H5NO2, extracellular region

Catalysed by

dipeptidase activity of DPEP1,2 dimers [plasma membrane]EC 3.4.13.18

Literature

Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity J Struct Biol, 2020
Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis J. Mol. Biol., 2002
Cloning and structural analysis of genomic DNA for human renal dipeptidase Biochim. Biophys. Acta, 1993
Gene structural analysis and expression of human renal dipeptidase Biotechnol. Prog., 1994