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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation

Phenytoin + O2 + NADPH + H+ → HPHT + H2O + NADP+

Reactome: R-HSA-212004
Compartment: endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea: None recorded

Inputs

PhenytoinCHEBI:8107, C15H12N2O2, endoplasmic reticulum lumen
O2CHEBI:15379, O2, endoplasmic reticulum lumen
NADPHCHEBI:16474, C21H30N7O17P3, endoplasmic reticulum lumen
H+CHEBI:15378, H, endoplasmic reticulum lumen

Outputs

HPHTCHEBI:63804, C15H12N2O3, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
NADP+CHEBI:18009, C21H29N7O17P3, endoplasmic reticulum lumen

Catalysed by

monooxygenase activity of Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane]

Literature

P450 2C18 catalyzes the metabolic bioactivation of phenytoin Chem Res Toxicol, 2005